Endocrine Abstracts

Patients with adrenal insufficiency need adjustment of the hydrocortisone (HC) dose during an intercurrent illness. Current recommendation to double the daily HC dose at each occasion does not consider the non-linear dose proportionality in bioavailability i.e. doubling the dose gives less than 100% increase in exposure. We have developed an intercurrent illness dose regimen for a once daily dual release HC tablet using population pharmacokinetic (POPPK) modeling.<p class=...

There is no consensus on the best dosing regimen for glucocorticoid replacement therapy. The general intention is to individualize according to the clinical response and use the lowest possible maintenance dose without risking adrenal crisis.Aim: To survey patients with adrenal insufficiency (AI) on their glucocorticoid replacement therapy dosing regimen.Method: Patients (children and adults) were recruited via patient organization...

Introduction: There are limited prospective safety data on glucocorticoid replacement. The aim of this study was to assess the safety and efficacy during long term treatment using a once-daily oral dual-release hydrocortisone in patients with adrenal insufficiency (AI).Methods: This is an open, multi-centre study in 71 patients with AI. Most patients were recruited from a previous controlled trial (n=53) where they had received the dual-release th...